|
Colorectal Neoplasms
|
0.900 |
AlteredExpression
|
group |
LHGDN |
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
|
16356174 |
2005 |
|
Colorectal Neoplasms
|
0.900 |
AlteredExpression
|
group |
LHGDN |
Expressions of two adenomatous polyposis coli and E-cadherin proteins on human colorectal cancers.
|
12647217 |
2003 |
|
Colorectal Neoplasms
|
0.900 |
AlteredExpression
|
group |
LHGDN |
Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary.
|
18369740 |
2008 |
|
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
BEFREE |
Then we used these assays for the analysis of MGMT and APC promoter methylation in a subset of archival formalin-fixed paraffin-embedded colorectal tumor specimens.
|
19179456 |
2009 |
|
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
LHGDN |
APC promoter hypermethylation contributes to the loss of APC expression in colorectal cancers with allelic loss on 5q.
|
15326380 |
2004 |
|
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
BEFREE |
Moreover, APC promoter hypermethylation is observed in approximately 20% of sporadic colorectal tumors and correlates with the loss of gene expression.
|
18027849 |
2008 |
|
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
LHGDN |
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
|
18451217 |
2008 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
TNIK inhibition abrogates colorectal cancer stemness.
|
27562646 |
2016 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
|
20707908 |
2010 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
APC and KRAS were mutated at significantly lower rates in tumors from patients with IBD than in sporadic colorectal tumors (13% and 20% of cases, respectively).
|
26764183 |
2016 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Most mutated APC proteins in colorectal tumors lack the beta-catenin-binding regions and fail to inhibit Wnt signaling, leading to the overproliferation of tumor cells.
|
17572842 |
2007 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
The APC gene is responsible for familial adenomatous polyposis and is considered to be a tumor suppressor gene associated with development of sporadic colorectal tumors.
|
1310068 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin.
|
12907644 |
2003 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
|
21967605 |
2011 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Colorectal tumors from APC*I1307K carriers principally harbor somatic APC mutations outside the A8 tract.
|
24416237 |
2014 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
These results support (i) that vitamin D, alone or in combination with calcium, may modify APC, β-catenin, and E-cadherin expression in humans in directions hypothesized to reduce risk for colorectal neoplasms; (ii) vitamin D as a potential chemopreventive agent against colorectal neoplasms; and (iii) the potential of APC, β-catenin, and E-cadherin expression as treatable, pre-neoplastic risk biomarkers for colorectal neoplasms.
|
27254743 |
2017 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
Colorectal cancers in a new mouse model of familial adenomatous polyposis: influence of genetic and environmental modifiers.
|
15502862 |
2004 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.
|
14522940 |
2003 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.
|
1541640 |
1992 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
The APC gene has been found to be mutated during the development of sporadic colorectal tumors as well as in the germ line of familial adenomatous polyposis patients.
|
8385345 |
1993 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
LHGDN |
Role of APC and DNA mismatch repair genes in the development of colorectal cancers.
|
14672538 |
2003 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
LHGDN |
Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.
|
11956815 |
2002 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
When combined with previously published data, our results show that there is interdependence of the "two hits" at APC in sporadic colorectal tumors as well as in FAP.
|
10737795 |
2000 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Thus, we suggest that oncogenic K-ras represents a key player during an alternative, serrated pathway to colorectal cancer and hence propose RAS-RAF-MEK signaling apart from APC as an additional gatekeeper in colorectal tumor development.
|
20708155 |
2010 |
|
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Dietary folate and APC mutations in sporadic colorectal cancer.
|
17116713 |
2006 |